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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name mmu-miR-200b
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Mus musculus
Tissues/Cell_line retinas
Methods RT-PCR, Western blot, CHIP-qPCR, ELISA, siRNA transfection
Expression pattern down-regulated
Functional description Human retinal microvascular endothelial cells exposed to high levels of glucose regulate miR-200b repression through histone methylation and that inhibition of PRC2 increases miR-200b while reducing VEGF.
PubMed ID 25884496
Year 2015
Title Polycomb repressive complex 2 regulates MiR-200b in retinal endothelial cells: potential relevance in diabetic retinopathy.
Drug-related ncRNA NO

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